Symbol
Name
ID

Inpp5d
inositol polyphosphate-5-phosphatase D
MGI:107357

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal granulocyte differentiation

abnormal mononuclear cell differentiation

abnormal monocyte differentiation

abnormal osteoclast differentiation

abnormal macrophage chemotaxis

increased mast cell degranulation

intestinal inflammation

ileum inflammation

enlarged thymus

small thymus

decreased thymocyte number

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal lymphopoiesis

abnormal B cell differentiation

decreased pro-B cell number

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal myelopoiesis

increased neutrophil cell number

increased dendritic cell number

abnormal lymphocyte cell number

absent marginal zone B cells

increased B-1 B cell number

decreased B cell number

decreased pre-B cell number

decreased NK cell number

increased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased osteoclast cell number

increased monocyte cell number

increased leukocyte cell number

abnormal lymphocyte morphology

abnormal NK cell morphology

abnormal osteoclast morphology

abnormal spleen marginal zone macrophage morphology

abnormal myeloid leukocyte morphology

abnormal leukocyte physiology

abnormal eosinophil physiology

abnormal neutrophil physiology

abnormal B cell physiology

increased IgG2a level

increased IgG level

increased IgM level

increased immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

abnormal osteoclast physiology

increased circulating interleukin-6 level

abnormal interferon level

abnormal interleukin level

abnormal lymph node germinal center morphology

enlarged lymph nodes

abnormal cell-mediated immunity

abnormal humoral immune response

increased interferon-beta secretion

abnormal interleukin secretion

increased tumor necrosis factor secretion

increased susceptibility to systemic lupus erythematosus

increased autoantibody level

increased anti-nuclear antigen antibody level

increased anti-chromatin antibody level

increased anti-double stranded DNA antibody level

increased anti-single stranded DNA antibody level

lung inflammation

decreased susceptibility to parasitic infection

decreased susceptibility to graft versus host disease

Availability

Mouse Genotype

Inpp5d^el20/Inpp5d^el20

Inpp5d^m1Anu/Inpp5d^m1Anu

Inpp5d^m1Btlr/Inpp5d^m1Btlr

Inpp5d^m2Btlr/Inpp5d^m2Btlr

Inpp5d^m4Btlr/Inpp5d^m4Btlr

Inpp5d^m5Btlr/Inpp5d^m5Btlr

Inpp5d^tm1.1Wgk/Inpp5d^tm1.1Wgk

Inpp5d^tm1Dmt/Inpp5d^tm1Dmt

Inpp5d^tm1Rkh/Inpp5d^tm1Rkh

Inpp5d^M3Btlr/Inpp5d⁺

Inpp5d^tm1Rav/Inpp5d^tm1Rav
Tg(Cd4-cre)1Cwi/? (conditional)

Cd79a^tm1(cre)Reth/Cd79a⁺
Inpp5d^tm1Rav/Inpp5d^tm1Rav (conditional)

Inpp5d^tm1Wgk/Inpp5d^tm1Wgk
Tg(Mx1-cre)1Cgn/0 (conditional)

Inpp5d^tm1Rav/Inpp5d^tm1.1Rav
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Inpp5d^tm1Wgk/Inpp5d^tm1.1Wgk
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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